Yasushi Hirota Selected Research

Endometriosis

11/2022	Elevated phosphorylation of estrogen receptor α at serine-118 in ovarian endometrioma.
7/2022	Long-term conservative management of symptomatic bladder endometriosis: A case series of 17 patients.
1/2021	Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages.
1/2021	CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model.
1/2020	The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages.
1/2020	Niclosamide suppresses macrophage-induced inflammation in endometriosis†.
1/2020	Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma.
1/2020	Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma.
12/2019	Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations.
11/2019	Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway.

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Yasushi Hirota Research Topics

Disease

56	Endometriosis 11/2022 - 07/2003
18	Inflammation (Inflammations) 01/2020 - 05/2003
7	Adenomyosis 01/2022 - 10/2014
7	Neoplasms (Cancer) 01/2021 - 04/2005
6	Pre-Eclampsia (Preeclampsia) 11/2019 - 05/2003
4	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 11/2021 - 01/2019
4	Infertility (Sterility) 01/2020 - 01/2016
4	Fibrosis (Cirrhosis) 07/2019 - 10/2005
4	Premature Birth (Birth, Premature) 09/2013 - 03/2010
4	Colitis 08/2005 - 04/2004
3	Hemorrhage 10/2020 - 10/2012
3	Ulcer 02/2005 - 04/2004
2	Obesity 01/2021 - 01/2017
2	Anemia 10/2020 - 10/2014
2	Uterine Hemorrhage (Uterine Bleeding) 10/2020 - 09/2020
2	Leiomyoma (Uterine Fibroids) 09/2020 - 12/2005
2	Hyperandrogenism 01/2020 - 01/2019
2	Hypoxia (Hypoxemia) 01/2019 - 10/2003
2	Pneumothorax 06/2018 - 09/2015
2	Endometrial Neoplasms (Endometrial Cancer) 07/2006 - 12/2005
1	Dysbiosis 11/2021
1	Pulmonary Embolism 10/2020
1	Hemorrhagic Shock 10/2020
1	Prolapse 09/2020
1	Polyps 01/2020

Drug/Important Bio-Agent (IBA)

8	dienogest FDA Link 10/2020 - 05/2008
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2005
7	EnzymesIBA 01/2020 - 10/2004
6	CytokinesIBA 01/2020 - 08/2008
6	Progestins (Progestagens)IBA 01/2020 - 03/2013
5	Messenger RNA (mRNA)IBA 01/2021 - 11/2005
5	Interleukin-8 (Interleukin 8)IBA 11/2014 - 10/2003
5	InterleukinsIBA 11/2012 - 10/2003
4	Gonadotropin-Releasing Hormone (GnRH)FDA Link 10/2020 - 04/2005
4	Progesterone FDA LinkGeneric 01/2020 - 12/2008
4	Estrogens (Estrogen)FDA Link 01/2016 - 12/2005
4	Proteinase-Activated ReceptorsIBA 01/2012 - 06/2005
4	AdiponectinIBA 02/2007 - 10/2005
4	Leukocyte Elastase (Neutrophil Elastase)IBA 08/2005 - 04/2004
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 05/2003
3	Aromatase (CYP19)IBA 12/2016 - 04/2013
3	Mechanistic Target of Rapamycin Complex 1IBA 01/2016 - 11/2011
3	Interleukin-6 (Interleukin 6)IBA 11/2014 - 07/2011
3	Interleukin-4 (Interleukin 4)IBA 04/2013 - 08/2008
3	Interleukin-17 (Interleukin 17)IBA 11/2012 - 03/2008
3	Thrombin FDA Link 10/2012 - 08/2003
3	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 10/2012 - 05/2003
3	Phenobarbital (Luminal)FDA Link 08/2005 - 04/2004
3	Peroxidase (Myeloperoxidase)IBA 02/2005 - 04/2004
2	Mitogen-Activated Protein KinasesIBA 11/2022 - 11/2004
2	AndrogensIBA 11/2021 - 01/2020
2	LigandsIBA 01/2021 - 02/2009
2	ChemokinesIBA 01/2021 - 07/2003
2	Hemoglobins (Hemoglobin)IBA 10/2020 - 10/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 01/2017
2	InterferonsIBA 01/2020 - 02/2019
2	Progesterone Receptors (Progesterone Receptor)IBA 12/2019 - 09/2014
2	AntralIBA 11/2019 - 01/2019
2	Oral ContraceptivesIBA 10/2019 - 01/2017
2	Therapeutic UsesIBA 12/2016 - 09/2014
2	ResveratrolIBA 04/2016 - 01/2016
2	Metformin (Glucophage)FDA LinkGeneric 01/2016 - 08/2007
2	Hormones (Hormone)IBA 10/2014 - 07/2009
2	Sirolimus (Rapamycin)FDA Link 09/2013 - 11/2011
2	activin AIBA 06/2013 - 07/2011
2	ImmunosorbentsIBA 06/2013 - 10/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2011 - 02/2009
2	OsteoprotegerinIBA 02/2009 - 10/2004
2	Estradiol (Delestrogen)FDA LinkGeneric 08/2007 - 12/2006
2	p38 Mitogen-Activated Protein KinasesIBA 12/2006 - 11/2004
2	N 30IBA 12/2005 - 04/2005
2	Sulfonic AcidsIBA 08/2005 - 02/2005
2	Prednisolone (Predate)FDA LinkGeneric 02/2005 - 04/2004
2	ONO 6818IBA 02/2005 - 10/2004
2	Acetic Acid (Vinegar)FDA LinkGeneric 10/2004 - 04/2004
1	Estrogen ReceptorsIBA 11/2022
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2022
1	Diphtheria ToxinIBA 01/2021
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2021
1	Endocrine DisruptorsIBA 01/2021
1	ProstaglandinsIBA 01/2021
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2021
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2021
1	Warfarin (Coumadin)FDA LinkGeneric 10/2020
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2020
1	AnticoagulantsIBA 10/2020
1	relugolixIBA 09/2020
1	Levonorgestrel (Plan B)FDA LinkGeneric 01/2020
1	Double-Stranded RNA (RNA, Double Stranded)IBA 01/2020
1	Niclosamide FDA Link 01/2020
1	IsoenzymesIBA 01/2020

Therapy/Procedure

6	Therapeutics 10/2020 - 08/2007
5	Hysterectomy 11/2022 - 07/2015
2	Oral Administration 09/2020 - 03/2010
2	Cystectomy 01/2019 - 07/2015
2	Cesarean Section (Caesarean Section) 02/2017 - 06/2005
1	Conservative Treatment 07/2022
1	Thrombectomy 10/2020
1	Blood Transfusion (Blood Transfusions) 10/2020
1	Contraception (Birth Control) 01/2020